DATE
August 10, 2023
CATEGORY
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Abstract:
The prevalence and severity of prelabor rupture of the membranes (PROM)/preterm PROM (PPROM) are a worldwide public health concern. PROM is the result of a cascade of events involving matrix metalloproteinase (MMP)-9, tissue inhibitor of metalloproteinases 1 (TIMP1), cytokines and proapoptotic genes, which is initiated by several factors such as infection, genotoxic agents or some unknown etiology.
In PROM, there is an increased expression and activation of MMP-2, MMP‑3 and MMP-9 and a reduction of TIMP1. p53 and tumor necrosis factor (TNF)-α mediate the major apoptotic pathway of PROM. p53 can transactivate some MMP genes, resulting in the overexpression of MMPs. This leads to apoptosis.
MMP‑2 and MMP‑9 degrades type-IV collagen, which is the major structural component of chorioamnion. Understanding the fundamental pathology at the molecular level, it appears necessary to adjust the biologically protective mechanism to prevent spontaneous preterm labor.
Our findings show that the novel combination of arginine, ascorbic acid, folic acid, glutamine, glutathione, thiamine, lactic acid bacillus spores, vitamin E acetate and pyridoxine is safe and effectively prevents PROM and PPROM (97% patients) and prolongs pregnancy term.
Keywords: Amino acids, vitamins, Lactobacillus spp., PROM, PPROM
Chairman and Head, Dept. of Obstetrics and Gynecology, Asian Institute of Medical
Sciences, Faridabad, Haryana
Address for correspondence
Dr Anita Kant
Chairman and Head, Dept. of Obstetrics and Gynecology, Asian Institute of Medical
Sciences, Faridabad, Haryana
E-mail: dranitakant@yahoo.com
Indian Journal of Clinical Practice, Vol. 33, No. 9, February 2023